The spread of the latest strain of the coronavirus (COVID-19) is disrupting economic and social life in multiple ways and dimensions. This crisis is unfolding at a time characterized by rapid digitalization, which is helping in the decision-making process regarding response and adaptations to the situation by governments, businesses and consumers. However, differences in digital readiness hamper the ability of large parts of the world to take advantage of these technologies. Multilateralism is vital in a world facing critical development challenges.