This discussion was launched as a means of sharing knowledge and documenting perspectives on how the African continent could better foster regional integration through overcoming the challenges of doing business in Africa, including travelling restrictions and visa requirements. It is acknowledged that great potential exists for Africas socioeconomic transformation, if the regional leadership could sufficiently leverage the advantages of regional integration in the continent. It is argued that, the most reliable and predictable strength for the continent is itself; a charge against the availability of vast natural resources, growing human talent and the demographic dividend that needs to be harnessed through increased regional integration. This knowledge brief summarises the discussions and ideas shared by the African Community of Practice (AfCoP) members with one of the key messages emerging being the need for building capable and effective regional economic communities founded on strong accountability systems. Moreover, the suggested recommendations include the need to increase regional political will and commitment to implementing regional protocol and policies; whereas AfCoP and regional institutions such as the African Capacity Building Foundation (ACBF) and their partners are called to increase capacity building efforts especially around advocacy for management for development results and culture including engaging regional leadership on issues such as the importance of effective regional integration for Africas transformation.