COVID-19 has firmly set foot on the African continent, affecting all African countries. Any failure to contain the virus in one country ultimately threatens the safety of others. This weakest link characteristic calls for a coordinated response across countries. Yet, the volume of analysis of international and national responses stands in contrast to what has been written or discussed about regional responses, particularly in Africa. This note summarises and reflects on the different roles played by the African Union and a sample of the continents regional organisations in shaping collective, coordinated regional responses