The 2nd Africa Conference on Tobacco Control and Development took place in Accra, Ghana, on 13-14 November 2024, with the theme Breaking Barriers, Building Futures. Organized by the African Capacity Building Foundation (ACBF) in partnership with the Centre for Tobacco Control in Africa (CTCA) and Youth in Action, and hosted by the Government of Ghana, the conference gathered experts, policymakers, and stakeholders to address the complex challenges of tobacco use across Africa. The event focused on enhancing the tobacco control ecosystem, exploring innovative approaches to smoking cessation, the role of youth and gender, the impact of emerging tobacco products, environmental concerns, and the sustainability of tobacco control funding. Participants engaged in plenary sessions, parallel tracks, and poster presentations, fostering collaboration and knowledge exchange. Key issues highlighted included the disproportionate impact of tobacco-related diseases on vulnerable populations, the tobacco industry's marketing strategies, and the critical need for regional collaboration. The conference reaffirmed the commitment of governments, civil society, and international organizations to the World Health Organization Framework Convention on Tobacco Control (WHO FCTC) and emphasized the importance of policies that prioritize public health. The event underscored the role of young advocates as leaders in tobacco control and affirmed the dedication to building a sustainable tobacco-free future for Africa.