The call to industrialize and modernize Africa has become more pressing in recent years especially given the high rates of youth unemployment. The African Unions Agenda 2063 and the Common African Position on Agenda 2030 identify science, technology, and innovation (STI) as key enablers to achieving this. In response, Africa adopted a 10-year Science, Technology, and Innovation Strategy (STISA2024). The African Capacity Building Foundation (ACBF) STI Survey (2016) confirms the importance of STI strategies and capacity development in African countries. This policy brief highlights the role of African governments in building STI capacity and the key capacity imperatives pertinent to STI. African governments are responsible for building STI capacity through the policies and processes that guide investment decisions in STI products and services.