This policy brief emphasizes the critical importance of incorporating gender and social equity considerations into climate adaptation programming within Africas agriculture sector. Climate change is already exerting a significant impact, but its effects are far from uniform. Marginalized communities, notably women and girls, bear a disproportionate burden due to pre-existing social, economic, and cultural disparities. The knowledge brief extensively explores the vulnerabilities and roles of women and marginalized groups, shedding light on the adverse effects of climate change on their lives. It underscores the importance of adopting gender-responsive and socially equitable approaches to effectively mitigate these effects. Furthermore, the analysis showcases a curated selection of case studies, each exemplifying initiatives that have made significant progress in addressing these complex challenges. These initiatives are notable for their dedication to gender mainstreaming, womens empowerment, and the implementation of gender-sensitive climate adaptation interventions. These case studies offer invaluable insights for replication and scaling up across the continent. Key lessons include promoting gender-transformative adaptation, providing training and technical assistance, enhancing womens participation in policy development, and improving data collection and analysis. In conclusion, this knowledge product serves issues a compelling call to incorporate gender and social equity considerations into climate adaptation policies and practices, particularly in Africas agriculture sector. It contributes to the development of a more resilient and equitable response to climate change in African agriculture, aligning with global sustainability goals. This approach ensures a more just and prosperous future by championing inclusivity and sustainability for all.