The COVID-19 crisis is affecting the entire world economy and that of Africa. Some key sectors of the African economy are already experiencing a slowdown as a result of the pandemic. Tourism, air transport, and the oil sector are visibly impacted. However, invisible impacts of COVID-19 are expected in 2020 regardless of the duration of the pandemic. It is important to assess the socio-economic impact of COVID-19, although the pandemic is at a less advanced stage in Africa due to its lesser quantity of international migrants arrivals relative to Asia, Europe, and North America, and strong precautionary measures in some African countries. African economies remain informal and very vulnerable to external shocks. In this study, three scenarios are constructed based on the description of specific key economic indicators in order to evaluate the potential impact of the pandemic on various dimensions of African economies. The impact on the African economy for each of the scenarios is presented, with a discussion of some of the key measures being taken by selected African Union Member States to mitigate the negative effects.