This Knowledge Brief synthesizes insights from the Tax Dialogue Webinar convened in March 2026 by the African Capacity Building Foundation (ACBF) on the theme "Digital Economy Taxation, a Key Lever for Strengthening Domestic Revenue Mobilization in Africa." It highlights the rapid growth of Africa's digital economy and the challenges existing tax systems face in capturing its value, including limited institutional capacity, information asymmetries, and outdated international tax rules. The Brief proposes practical measures to enhance domestic revenue mobilization, such as modernizing tax laws, strengthening VAT frameworks, investing in digital tax administration, and promoting regional cooperation. It draws on country experiences from Nigeria, Uganda, and Zambia. The publication concludes by emphasizing the need for a balanced approach that mobilizes revenue while supporting innovation and inclusive growth, advocating for forward-looking reforms and active engagement in global tax governance to secure fair taxing rights for African nations.