This policy brief by the African Capacity Building Foundation (ACBF) notes that African countries have shown interest and willingness in developing their economies through an approach driven by science, technology, and innovation (STI). Agenda 2063 and the Common African Position on Agenda 2030 identify STI as a key enabler to achieving inclusive and sustainable development in Africa. The ACBFs STI Survey (2016) confirms the importance of STI strategies and capacity development in African countries. The survey findings point to African institutions of higher learning as having a crucial role in building Africas STI capacity. Thus, it is imperative that these institutions create appropriate systems that produce well-trained human capital in STI and other sector-specific critical technical skills. This entails refocusing investment priorities towards accumulating STI infrastructure, creating and strengthening partnerships, and redesigning curricula to meet Africas needs.